02/12/2026
Intravenous Thrombolysis for Minor Acute Ischemic Stroke
Intravenous thrombolysis lowered functional independence and increased deaths at 90 days
TheNNT Rating System
The Green Rating
Therapies rated green are the best you can get
Therapies rated green are the best you can get
The Yellow Rating
Therapies rated yellow require more studies OR therapies with equal efficacy.
Therapies rated yellow require more studies OR therapies with equal efficacy.
The Red Rating
Red suggest that benefits and harms may be equal or equivocal.
Red suggest that benefits and harms may be equal or equivocal.
The Black Rating
Therapies rated black have very clear harms without any benefit.
Therapies rated black have very clear harms without any benefit.
Highlighted Reviews
01/29/2026
Noninvasive Respiratory Support for Pediatric Acute Hypoxemic Respiratory Failure
Continuous positive airway pressure (CPAP) reduced risk of invasive mechanical ventilation (IMV) compared to standard oxygen therapy (SOT), while both CPAP and high-flow nasal cannula (HFNC) reduced treatment failure compared to SOT
10/07/2025
Balanced Crystalloids for Pediatric Sepsis and Septic Shock
Balanced crystalloids reduced the risk of renal replacement therapy requirement when compared to normal saline
Recent Reviews
09/23/2025
Effect of Vitamin D Supplementation on Prevention of Acute Respiratory Infections
Vitamin D supplementation does not reduce the risk of acute respiratory infections (ARI)
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08/28/2025
Fidaxomicin vs Vancomycin for Clostridioides difficile Infection
Fidaxomicin treatment resulted in a higher chance of sustained clinical resolution
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08/26/2025
Safety of Treating Low-Risk Patients with Acute Pulmonary Embolism at Home
The incidence of mortality and/or adverse events in low-risk patients with PE (selected by a validated risk stratification tool) is very low
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08/19/2025
Early versus Delayed Colonoscopy for Acute Lower Gastrointestinal Bleeding
Early colonoscopy within 24 h of presentation does not improve clinical outcomes such as further bleeding or mortality in patients hospitalized with acute LGIB
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08/12/2025
Efficacy of Tirzepatide, Retatrutide, and Semaglutide for Weight Loss in Obese Individuals Without Diabetes
Glucagon-like peptide-1 receptor agonists and co-agonists are effective for weight loss in obese patients without diabetes who can tolerate the drug's adverse events
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05/29/2025
Corticosteroids for Community-Acquired Bacterial Pneumonia
Corticosteroids reduced mortality (only for severe CAP), reduced need for invasive mechanical ventilation (intubation) and ICU admission as well as length of hospital and ICU stay
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