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Source

ISIS­2: Randomized trial of intravenous streptokinase, oral aspirin, both, or neither among 17187 cases of suspected acute myocardial infarction. Lancet. 1988 Aug 13;2(8607):349-60.

Efficacy Endpoints

Death at 1 month following major heart attack (STEMI)

Harm Endpoints

Major bleeding (brain bleeding or bleeding requiring transfusion) and minor bleeding.

Narrative

The lone high quality trial addressing this question was multi-institutional across the U.S and Western Europe and was a randomized controlled trial of over 17000 subjects. Subjects were believed to be suffering acute MI by treating physicians and were randomized to aspirin, a thrombolytic (‘clot-busting’ medication), both, or neither. The groups were similar. There was increased death in the first month among those assigned to placebo 1016/8600 (11.8%) versus those assigned to aspirin 811/8587 (9.4%) with no significant increase in transfusion or intracerebral hemorrhage. There was a 0.6% increase in minor bleeding.

Aspirin provides among the best mortality benefits of any intervention for MI, with minimal downside. The anti-platelet mechanism seems sensible and the data is strong. Aspirin should be given to all cases of confirmed or suspected STEMI unless a significant contraindication exists.

Caveats

We don’t know for certain that the patients entered into this trial were having heart attacks, as the entry criterion was an EKG showing ST elevation and MI was not confirmed with any other testing (i.e. cardiac biomarkers). There has been no attempt to confirm these results (there probably never were).

Author

Joshua Quaas, MD

Published/Updated

November 28, 2009